Glycation - How To Stop AGE-ing

What is Glycation?

As we age, our skin undergoes various changes, from wrinkles and fine lines to a loss of elasticity. While many factors contribute to these signs of aging, one often-overlooked process is glycation. In this article, we’ll delve into what glycation is, how it affects the body, and practical ways to mitigate its impact on aging.

Glycation is a biochemical reaction that occurs when sugar molecules bind to proteins or lipids without the help of enzymes. This non-enzymatic reaction creates what are known as Advanced Glycation End-products (AGEs). Unlike other biochemical processes that are carefully regulated, glycation happens spontaneously, and the AGEs that result from this process can accumulate over time, leading to various health issues.

At a molecular level, it involves the attachment of sugar molecules, such as glucose or fructose, to proteins and lipids in the body. These sugars form a bond with amino acids in the proteins, which can alter the structure and function of these molecules. This process is detrimental because it produces AGEs, which can disrupt normal cellular functions.

In addition to creating AGEs, it also leads to the formation of reactive oxygen species (ROS), which are harmful by-products that contribute to oxidative stress. Oxidative stress can further damage proteins, lipids, and DNA, accelerating the aging process and increasing the risk of chronic diseases.

It has a significant impact on the skin, which is one of the most visible areas affected by aging. Here’s how glycation contributes to skin aging:

1. Collagen and Elastin Damage: Collagen and elastin are two key proteins in the skin that provide structure, firmness, and elasticity. It can damage these proteins by cross-linking them, which reduces their flexibility and strength. This leads to wrinkles, sagging, and a loss of skin elasticity.

2. Skin Texture and Tone: The accumulation of AGEs in the skin can affect its texture and tone. AGEs can cause the skin to become rougher and more uneven, leading to a dull appearance. Additionally, it can impair the skin’s ability to repair itself, exacerbating signs of aging.

3. Inflammation: It can trigger inflammatory responses in the skin. Chronic inflammation contributes to skin aging by breaking down collagen and elastin fibers and impairing the skin’s repair mechanisms. This can result in increased redness, puffiness, and uneven skin tone.

While it is particularly evident in the skin, it also has broader implications for overall health. The accumulation of AGEs has been linked to several chronic conditions, including:

1. Cardiovascular Disease: AGEs can contribute to the development of atherosclerosis by promoting inflammation and oxidative stress in blood vessels. This can lead to an increased risk of heart disease and stroke.

2. Diabetes: High blood sugar levels accelerate it, and the AGEs produced can exacerbate insulin resistance. This creates a vicious cycle where diabetes progresses and further accelerates the formation of AGEs.

3. Kidney Disease: AGEs can accumulate in the kidneys, leading to kidney damage and impaired function. This is particularly concerning for individuals with diabetes, as they are already at higher risk for kidney-related issues.

How to Combat Glycation

Enter, Equanimous. 

Now Alchemy Equanimous is the alchemy of two most anti-AGEing ancient remedies; 24K Gold Ormus and Himalayan Shilajit.

There are many, many benefits and ways to use Equanimous, and for anti-AGEing it is best to take a dripper full in your water with every meal to naturalize food related oxidation.

Consuming a diet low in sugar and refined carbohydrates can help reduce the formation of AGEs. Focus on eating whole foods, including plenty of fruits, vegetables, lean proteins, and whole grains. Foods rich in antioxidants, such as berries, green leafy vegetables, and nuts, can help combat oxidative stress and reduce AGE formation.

Staying well-hydrated is crucial for maintaining skin elasticity and reducing the impact of it. Drink plenty of water throughout the day to keep your skin and body hydrated.

Incorporate foods and supplements rich in antioxidants, such as vitamins C and E, to help neutralize free radicals and reduce oxidative stress. Antioxidants can also support skin health and reduce the visible signs of aging.

Physical activity can improve insulin sensitivity and help regulate blood sugar levels, reducing the risk of excessive it. Exercise also promotes overall health and supports healthy skin.

Choose skincare products with ingredients that can combat it. For example, products containing vitamin C, retinoids, and peptides can help improve collagen production and reduce the visible effects of glycation.

UV radiation can exacerbate the effects of it by increasing oxidative stress and damaging skin proteins. Protect your skin by using sunscreen and wearing protective clothing when outdoors.

Avoid smoking and excessive alcohol consumption, as these can increase oxidative stress and accelerate skin aging. A healthy lifestyle that includes adequate sleep and stress management can also support overall well-being and reduce the impact of it.